Showing posts with label synthetic biology. Show all posts
Showing posts with label synthetic biology. Show all posts

Aug 17, 2016

SynBERC, anthropological inquiry and methods of research

Recently I've been searching for guidance on how to describe ethnographic methodology in a grant proposal and found P. Rabinow and A. Stavrianakis' commentary Movement space: Putting anthropological theory, concepts, and cases to the test, where they reflect on the challenges of anthropological inquiry, on what it means to observe in heterogeneous and changing spaces. I had no time to read it slowly and carefully, so now just filling this gap.

The essay is a response to another collection of essays, but also a reflection on previous ethnographic research with Synthetic Biology Engineering Research Center SynBERC (I wish I paid more attention to it during my own dissertation research). An honest public account like that contributes to the ethics and methodology discussions more than any published "research" article.
Raising the question of "to what end" in anthropological inquiry, Rabinow and Stavrianakis' essay recollects previous collaborative participant-observations as attempts to bring the ethics that exists outside of the instrumental rationality of science into multidisciplinary research projects.

Flourishing is the concept they used to challenge and change the currently existing relations between knowledge and care (see Rabinow, Paul. "Prosperity, Amelioration, Flourishing: From a Logic of Practical Judgment to Reconstruction." Law and Literature 21, no. 3 (2009): 301-20, jstor). Flourishing helps to examine research practices from a holistic perspective, as practices that are performed by human beings without ethical compartmentalization into scientific, individual, and citizen values.

Then the discussion moves to temporality in anthropological research and the distinction between "contemporary" and "present" in ethnography. This distinction was hard for me to understand. Observations are made in the present, but somehow contextualization with experiences from the past (history) helps to challenge the "ethnographic present". Does it mean that something (objects or practices) maybe present but not contemporary? Or that contemporary may include the past? In other words, the distinction present vs contemporary vs modern allows us to stay tuned to the constant changes and not to fix descriptions as existing in certain times only. Sometimes it seemed that contemporary referred to attempts to reconcile diverse or contradicting practices (e.g., the practices of observation and observers and the practices of the observed).

An interesting point was made on citation (again, as a response to someone else's point). It is about acknowledging more recent work on similar issues.  Understanding that that's rules of the game (esp. to get grants), Rabinow writes that excessive citation also constrains thinking and writing, and authorizes such practices. Why would someone go back to reading and citing Weber, Foucault, or Dewey? Not because what they said is still relevant and true (althrough some of it is), but because they paid so much attention to problem formation, to the need for conceptual tools, and to the importance of experimentation with form.

Back to SynBERC, it is striking how empty expressions of support from bioscientists and engineers masked indifference and ultimately lack of respect and willingness to change. What made things worse was that social scientists' effort to develop effective modes of governance and interaction were blocked and downgraded to non-action and "soothing public relations". Moreover, the social scientists themselves failed to coordinate and reflect on their complicity with dominating technoscientific norms and values.

Even though I really appreciated this account of anthropological "failure" (as seen by others, but not by the authors who conceptualize it as an "anthropological test"), there is a larger purpose in it. As the authors put it,
... it is time to thematize the new configurations of power relations in which anthropologists are working today. Critique as denunciation, still the dominant mode in anti-colonial narratives, is no longer sufficient for the complexities of contemporary inquiry. We are arguing for a more fine-grained acceptance of the fact that by refusing the binaries of inside and outside, one’s responsibility for one’s position in the field is made available for reflection and invention.
Anthropology's major task is to map heterogeneity of human and cultural forms, including:
  • cultural heterogeneity with an underlying generality (American anthropology)
  • heterogeneity within common institutional forms such as kinship and law (British anthropology)
  • variations in structural patterns of society and the mind (French anthropology)
However, accounts of heterogeneity lost their force, in some ways losing their criteria of validity under the pressure of current norms of conducting research. At the same time critical evaluation of such criteria is an important task in changing present times. Such evaluation can be done through testing - constant re-evaluation of the existing conceptual tools in the context of new situations and experiences. The rest of the detailed discussion on testing was dense, but less relevant to me, so it was also harder to follow. 

One of the take-aways is that anthropology needs to be a collaborative endeavor, where individual inquiries examine specific cases and then many inquirers create a common space of concepts, problems, and cases. The constant movement between specific cases and topology of cases creates a space where anthropology can make justifiable warrantable claims about more than one case, i.e., about heterogeneity and associated generality.


Sep 23, 2014

Summer school on synthetic biology

During the week of September 15-19, 2014 I participated in the summer school on societal implications of synthetic biology. Organized by Kristin Hagen and Margret Engelhard from the European Academy of Technology and Innovation Assessment and by Georg Toepfer from the Center for Literary and Cultural Research Berlin, it was held in Berlin, Germany, at the Center for Literary and Cultural Research.

Participants came from different countries - Austria, Italy, Germany, the Netherlands, Canada and the United States. Similarly, their backgrounds were quite diverse - biology, chemistry, philosophy, sociology, political science, and communications. The main goal of the school was to have an interdisciplinary discussion about synthetic biology as an emerging area of science and its implications for society. Participants wrote papers and presented them at the school. Additionally, several experts from various fields gave their talks. Below is a short summary of what we talked about:

The meanings and metaphors of life. Synthetic biology inevitably raises questions related to our understandings of life. On one hand, there is no universal definition of life and both philosophers and scientists continue to ponder over whether it is even possible to come up with such a definition. On the other hand, there may be no need for such definition, because a) we have an intuitive understanding of what life is and adapt as it changes, and b) having limited definitions works for specific purposes, such as understanding of how to create an artificial cell or argue against the scientific possibility of creating life from scratch. Metaphors that we use to answer the grand questions of life or to promote scientific advancements in synthetic biology bring together the domains of nature, artificiality, control, and aesthetics. Those metaphors are not “innocent” as they open some opportunities and close others.

Synthetic biology (SB) as a field. Synthetic biology is not a homogeneous discipline, it is a fuse of approaches that draw on synthetic chemistry, genetic engineering, and bioinformatics. The engineering of metabolic pathways, which allows to use bacteria and other microorganisms to produce chemicals, plays an important role in SB breakthroughs. Chemical synthesis of DNA, which allows a synthesized DNA to be inserted into an existing organism, is another important area of synthetic biology. The presentations that explained various types and flavors of synthetic biology talked about cells, pathways, chassis, microbes, reproduction, and evolution; they were colorful and full of exciting possibilities. We talked about promises of synthetic biology a lot, but I don’t think that science necessarily needs promises to justify its existence. As someone pointed out, science is a quest for knowledge, it should be interesting and exciting as such. I’m not sure science is a pure quest for knowledge, considering the convergences between science, technology, and industry. Nevertheless, I completely agree that it is exciting to learn about the world even if it's not clear whether this knowledge has applications.

Forms of communication and public dialog. Previous debates, such as the mad cow disease or GMO debate, and the resulting negative reactions demonstrate the importance of transparency in public communication of science. Early public engagement is seen as a way to improve understanding and acceptance of technology. On the other hand, the goal is not simply to promote public understanding and acceptance of technoscience, but rather to let voices of the public contribute to decision-making and regulatory frameworks. Many forms of public engagement, including polls, surveys, citizen panels, public discussions, and so on, have been promoted in the EU, and the results seem to indicate that even though not many people have heard about synthetic biology, many see continuities with previous scientific advancements and technologies and are willing to consider both positive and negative aspects of it.

Even from the short overview above it is obvious that there is a great diversity in the issues surrounding synthetic biology and approaches to their evaluation. Can they be integrated or synthesized? My own suggestion is to take a problem- rather than a debate-oriented approach and look for solutions to specific problems, while avoiding taking things for granted. Everyone has their interests and values and even the best intentions may result in bad outcomes. To use M. Foucault’s approach, we need to examine the order of things and the complex arrangements of what’s visible and hidden and what or who is included and excluded.

It was a week of stimulating discussions. The atmosphere was very friendly and collegial, and the disagreements were often phrased as humorous, slightly sarcastic remarks over dinner or drinks. My take-away from this summer school is that interdisciplinary dialog is possible, necessary, and fruitful. It works provided that we have ample time to interact and go beyond formalities (i.e., beyond formal presentations and opinion polls). The school has ended, but the work continues. We will revise our papers based on collective feedback, and they will become chapters in a forthcoming book.

See also:

Mar 19, 2012

ELSI for synthetic biology

A workshop held in 2010, at the Woodrow Wilson International Center for Scholars in Washington, DC, developed a list of ethical, legal, and social implications (ELSI) for synthetic biology. These implications are now available for public evaluation in the form of a survey (link).

May 22, 2010

Synthetic cell

Another achievement in synthetic biology - researchers say they created a synthetic cell. According to the press release from the J. Craig Venter Institute (JCVI), where the cell was constructed, the bacterial DNA of one bacterium (M. mycoides) was assembled from small fragments and grown in yeast cells. Then an error correction method that allowed to make sure that this synthetic DNA was viable has been developed. Then the synthetic bacterial DNA of M. mycoides was transplanted into another bacterium, Mycoplasma capricolum, where it started producing proteins. The initial genome was either destroyed or lost during replication and after two days there were viable M. mycoides cells rather than M. capricolum.

There are many issues here (including the White House finally getting interested in all this), but I'd like point a couple of things:

  • Other scientists quoted in newspapers downplay the achievement by saying that it's not a big deal or that it's not a creation of new life anyway. Why? It can be a journalistic way of presenting "diverse" viewpoints, a clash of scientific paradigms, jealousy, or something else.
  • In previous reports about the synthesis of life forms (e.g., in February 2008) the companies that provided DNA cassettes were usually omitted. Now the provider Blue Heron in also in the news. It can be nothing. Or something related to ownership, commercial interests, patenting, etc.
  • The project was funded by Synthetic Genomics, which has a contract from Exxon to generate biofules from algae. So while Dr. Venter tries to present the achievement of JCVI as an advance that raises philosophical, epistemological and other questions (and it does), the goal of all this is profit. And it means that if we want the ultimate questions of life, the universe and everything to be sufficiently addressed, it must be done by somebody else. Who?

Mar 11, 2010

Biosecurity webcast

A meeting at Wilson International Center for Scholars discusses the issues of biosecurity in the context of synthetic biology and DIY biology (http://wilsoncenter.org/index.cfm?topic_id=1414&fuseaction=topics.event_summary&event_id=601732). Here are some notes from their webcast.

Jason Bobe, co-founder of DIYbio:
  • Synthetic biology is on the rise, there are a lot of people who are interested in "doing" biology.
  • DIYbio is a community of people who are involved in genetic experiments.
  • There are different groups of people involved: entrepreneurs, amateurs, hackers, artists, moonlighters, educators, etc.
  • People from DIYbio are working on projects such as doing genetic self-testing, trying to replicate studies done at university labs, generating ideas.
  • Possible futures - biosurveillance, or distributed biosecurity, where everybody has the ability to evaluate the security of water; competitions among non-institutional participants in biology; involvement with synthetic biology.
  • Question about biosecurity: Who gets access to the equipment and techniques? Amateurs want to engage with synthetic biology, but this poses some issues. Possible models to look at: other amateur communities such as scuba diving and its practices of licensing, certification, etc.
Edward You, a special agent with the FBI Weapons of Mass Destruction Directorate, Countermeasures Unit, Bioterrorism Team:
  •  Challenges of synbio biosecurity - living organisms are harder to manage and contain; multiple communities and cultures bring misconceptions and misperceptions
  • Increased restrictions may not work, we need a culture of responsibility - something like neighborhood watch, when everybody watches everybody else.
  • FBI Synthetic Biology Tripwire Initiative - mechanism to prevent unauthorized purchase of dangerous pathogens or toxins by contacting FBI WMD coordinators, who then report to WMD directorate and all related agencies.
  • FBI engages in activities of mitigating the potential risks by outreach, partnerships, and information sharing.